Synthesis and Preliminary Evaluation of Novel 1, 5- Benzothiazepine Derivatives as Anti-lung Cancer Agents

A series of novel 1, 5-benzothiazepine derivatives having a biologically active thiazepine moiety was synthesized by the condensation of substituted chalcones with 2-aminothiophenol using conventional as well as non-conventional methods. The structures of the newly synthesized compounds were confirmed by FTIR, 1 H NMR, 13 C NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against human lung cancer cell line (A549) using Adriamycin as a reference drug.